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  • 3,4,5-三咖啡酰奎宁酸

    3,4,5-Tricaffeoylquinic acid

    3,4,5-三咖啡酰奎宁酸
    产品编号 CFN90238
    CAS编号 86632-03-3
    分子式 = 分子量 C34H30O15 = 678.59
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The herbs of Aconitum koreanum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3,4,5-三咖啡酰奎宁酸 CFN90238 86632-03-3 1mg QQ客服:2056216494
    3,4,5-三咖啡酰奎宁酸 CFN90238 86632-03-3 5mg QQ客服:2056216494
    3,4,5-三咖啡酰奎宁酸 CFN90238 86632-03-3 10mg QQ客服:2056216494
    3,4,5-三咖啡酰奎宁酸 CFN90238 86632-03-3 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universiti Malaysia Pahang (Malaysia)
  • National Cancer Center Research Institute (Japan)
  • The Australian National University (Australia)
  • University of Maryland (USA)
  • University of Helsinki (Finland)
  • Charles University in Prague (Czech Republic)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Shanghai University of TCM (China)
  • Yale University (USA)
  • Korea Food Research Institute(KFRI) (Korea)
  • Aarhus University (Denmark)
  • University of Queensland (Australia)
  • Sanford Burnham Medical Research Institute (USA)
  • Auburn University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nutrients.2021, 13(8):2901.
  • Chemistry of Natural Compounds2020, 56,423-426
  • Toxicol Rep.2021, 8:1131-1142.
  • Pharmacogn J.2022, 14(2):350-357
  • Processes2022, 10(10), 2008.
  • Br J Pharmacol.2020, 10.1111
  • Drug Test Anal.2018, 10(10):1579-1589
  • BMC Cancer. 2021, 21(1):91.
  • Applied Biological Chemistry2020, 63:33(2020)
  • J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
  • J Cell Mol Med.2020, 24(21):12308-12317.
  • Sci Rep.2018, 8(1)
  • J Appl Biol Chem2021, 64(3):245-251.
  • Life (Basel).2021, 11(7):616.
  • Nat Commun.2021, 12(1):681.
  • Food Chem Toxicol.2020, 135:110863
  • Phytother Res.2023, 37(10):4587-4606.
  • LWT - Food Science and Technology2022, 164:113627
  • Phytother Res.2019, 33(3):676-689
  • Spectrochim Acta A2019, 210:372-380
  • Arch Biochem Biophys.2020, 687:108384.
  • Int J Mol Sci.2021, 22(19):10220.
  • Cell.2018, 172(1-2):249-261
  • ...
  • 生物活性
    Description: 3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression-mediated activation of the Akt, ERK and NF-ĸB pathways, it may exert an inhibitory effect against the pro-inflammatory mediator-induced skin disease. 3,4,5-Tricaffeoylquinic acid may attenuate the proteasome inhibitor-induced programmed cell death in PC12 cells by suppressing the activation of the mitochondrial pathway and the caspase-8- and Bid-dependent pathways, the effect be attributed to its inhibitory effect on the formation of reactive oxygen species and depletion of GSH.
    Targets: HIV | TNF-α | Akt | NF-kB | Beta Amyloid | Bcl-2/Bax | p53 | Caspase | p53 | IL Receptor | ERK
    In vitro:
    Int Immunopharmacol. 2011 Nov;11(11):1715-23.
    3,4,5-Tricaffeoylquinic acid inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways.[Pubmed: 21704193]
    Keratinocytes may play an important role in the pathogenesis of skin disease in atopic dermatitis. Caffeoyl derivatives are demonstrated to have anti-inflammatory and anti-oxidant effects. However, the effect of 3,4,5-Tricaffeoylquinic acid prepared from Aconium koreanum on the pro-inflammatory cytokine-stimulated keratinocyte responses remains uncertain.
    METHODS AND RESULTS:
    In human keratinocytes, we investigated the effect of 3,4,5-Tricaffeoylquinic acid on the tumor necrosis factor (TNF)-α-stimulated production of inflammatory mediators in relation to the nuclear factor (NF)-κB and cell signaling Akt, which regulates the transcription genes involved in immune and inflammatory responses. 3,4,5-Tricaffeoylquinic acid inhibited the TNF-α-stimulated production of cytokines (IL-1β and IL-8) and chemokine (CCL17 and CCL27) in keratinocytes. Bay 11-7085 (an inhibitor of NF-κB activation) and Akt inhibitor attenuated the TNF-α-induced formation of inflammatory mediators. 3,4,5-Tricaffeoylquinic acid, Bay 11-7085, Akt inhibitor and N-acetylcysteine inhibited the TNF-α-induced activation of NF-κB, activation of Akt, and formation of reactive oxygen and nitrogen species. The results show that 3,4,5-Tricaffeoylquinic acid seems to attenuate the TNF-α-stimulated inflammatory mediator production in keratinocytes by suppressing the activation of Akt and NF-κB pathways which may be mediated by reactive oxygen species.
    CONCLUSIONS:
    The findings suggest that 3,4,5-Tricaffeoylquinic acid may exert an inhibitory effect against the pro-inflammatory mediator-induced skin disease.
    Pharmacology. 2012;90(3-4):183-92.
    3,4,5-tricaffeoylquinic Acid inhibits the lipopolysaccharide-stimulated production of inflammatory mediators in keratinocytes.[Pubmed: 22947851 ]
    Microbial product lipopolysaccharide (LPS) has been shown to be involved in the pathogenesis of inflammatory skin diseases. Caffeoyl derivatives have demonstrated anti-inflammatory and antioxidant effects. However, the effect of 3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) on the production of microbial product-induced inflammatory mediators in keratinocytes has not yet been studied.
    METHODS AND RESULTS:
    Using human keratinocytes, we investigated the effect of 3,4,5-Tricaffeoylquinic acid on the LPS-stimulated production of inflammatory mediators in relation to the nuclear factor (NF)-ĸB, Akt and ERK pathways. 3,4,5-Tricaffeoylquinic acid inhibited the LPS-induced expression of Toll-like receptor 4, and the production of cytokines and chemokines in keratinocytes. 3,4,5-Tricaffeoylquinic acid, Bay 11-7085, Aĸt inhibitor and ERK inhibitor each attenuated the LPS-induced production of inflammatory mediators by inhibiting the NF-ĸB, Akt and ERK pathways.
    CONCLUSIONS:
    3,4,5-Tricaffeoylquinic acid may attenuate the LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression-mediated activation of the Akt, ERK and NF-ĸB pathways. 3,4,5-Tricaffeoylquinic acid may exert a preventive effect against microbial product-induced inflammatory skin diseases.
    In vivo:
    Aging (Albany NY) . 2019 Jan 17;11(2):401-422.
    3,4,5-Tricaffeoylquinic acid induces adult neurogenesis and improves deficit of learning and memory in aging model senescence-accelerated prone 8 mice[Pubmed: 30654329]
    Abstract Caffeoylquinic acid (CQA) is a natural polyphenol with evidence of antioxidant and neuroprotective effects and prevention of deficits in spatial learning and memory. We studied the cognitive-enhancing effect of 3,4,5-tricaffeoylquinic acid (TCQA) and explored its cellular and molecular mechanism in the senescence-accelerated mouse prone 8 (SAMP8) model of aging and Alzheimer's disease as well as in human neural stem cells (hNSCs). Mice were fed with 5 mg/kg of TCQA for 30 days and were tested in the Morris water maze (MWM). Brain tissues were collected for immunohistochemical detection of bromodeoxyuridine (BrdU) to detect activated stem cells and newborn neurons. TCQA-treated SAMP8 exhibited significantly improved cognitive performance in MWM compared to water-treated SAMP8. TCQA-treated SAMP8 mice also had significantly higher numbers of BrdU+/glial fibrillary acidic protein (GFAP+) and BrdU+/Neuronal nuclei (NeuN+) cells in the dentate gyrus (DG) neurogenic niche compared with untreated SAMP8. In hNSCs, TCQA induced cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling. The neurogenesis promoting effect of TCQA in the DG of SAMP8 mice might explain the cognition-enhancing influence of TCQA observed in our study, and our hNSCs in aggregate suggest a therapeutic potential for TCQA in aging-associated diseases. Keywords: BMP signaling; SAMP8; TCQA; neurogenesis; spatial learning and memory.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.4736 mL 7.3682 mL 14.7364 mL 29.4729 mL 36.8411 mL
    5 mM 0.2947 mL 1.4736 mL 2.9473 mL 5.8946 mL 7.3682 mL
    10 mM 0.1474 mL 0.7368 mL 1.4736 mL 2.9473 mL 3.6841 mL
    50 mM 0.0295 mL 0.1474 mL 0.2947 mL 0.5895 mL 0.7368 mL
    100 mM 0.0147 mL 0.0737 mL 0.1474 mL 0.2947 mL 0.3684 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4-O-咖啡酰-3-O-丁香酰奎宁酸; 4-O-Caffeoyl-3-O-syringoylquinic acid CFN95430 1207645-17-7 C25H26O13 = 534.5 5mg QQ客服:1457312923
    异绿原酸B; Isochlorogenic acid B CFN99119 14534-61-3 C25H24O12 = 516.45 20mg QQ客服:1457312923
    3,4-二咖啡酰奎宁酸乙酯; Ethyl 3,4-dicaffeoylquinate CFN91970 143051-73-4 C27H28O12 = 544.50 5mg QQ客服:2056216494
    3,4-O-二咖啡酰基奎宁酸甲酯; 3,4-Di-O-caffeoylquinic acid methyl ester CFN90856 114637-83-1 C26H26O12 = 530.5 5mg QQ客服:2056216494
    异绿原酸A; Isochlorogenic acid A CFN99118 2450-53-5 C25H24O12 = 516.45 20mg QQ客服:1457312923
    3,5-二咖啡酰-表-奎宁酸; 3,5-Dicaffeoyl-epi-quinic acid CFN91944 879305-14-3 C25H24O12 = 516.45 5mg QQ客服:3257982914
    3,5-O-二咖啡酰基奎宁酸甲酯; 3,5-Di-O-caffeoylquinic acid methyl ester CFN90857 159934-13-1 C26H26O12 = 530.5 5mg QQ客服:215959384
    异绿原酸C; Isochlorogenic acid C CFN99120 32451-88-0 C25H24O12 = 516.45 20mg QQ客服:215959384
    异绿原酸C 4'-O-葡萄糖; Isochlorogenic acid C 4'-O-glucoside CFN95405 N/A C31H34O17 = 678.6 5mg QQ客服:2056216494
    4,5-O-二咖啡酰基奎宁酸甲酯; 4,5-Di-O-caffeoylquinic acid methyl ester CFN90858 188742-80-5 C26H26O12 = 530.5 5mg QQ客服:2056216494

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