Info: Read More
  • 中药标准品生产商,产品定制服务
  • (25RS)-鲁斯可皂苷元

    (25RS)-Ruscogenin

    (25RS)-鲁斯可皂苷元
    产品编号 CFN90898
    CAS编号 874485-32-2
    分子式 = 分子量 C27H42O4 = 430.62
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The leaves of Nolina microcarpa S. Wats.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    (25RS)-鲁斯可皂苷元 CFN90898 874485-32-2 1mg QQ客服:215959384
    (25RS)-鲁斯可皂苷元 CFN90898 874485-32-2 5mg QQ客服:215959384
    (25RS)-鲁斯可皂苷元 CFN90898 874485-32-2 10mg QQ客服:215959384
    (25RS)-鲁斯可皂苷元 CFN90898 874485-32-2 20mg QQ客服:215959384
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Amsterdam (Netherlands)
  • University of Wuerzburg (Germany)
  • University of Lodz (Poland)
  • Celltrion Chemical Research Institute (Korea)
  • Ateneo de Manila University (Philippines)
  • National Cancer Center Research Institute (Japan)
  • Pennsylvania State University (USA)
  • Utah State University (USA)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • University of Dicle (Turkey)
  • University of East Anglia (United Kingdom)
  • Mahatma Gandhi University (India)
  • Chulalongkorn University (Thailand)
  • Sant Gadge Baba Amravati University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • The Malaysian journal of pathology2019, 41(3):243-251
  • J Pharmaceutical and Biomedical Analysis2022, 114631.
  • Food Sci Biotechnol.2023, 32(7):997-1003.
  • Molecules.2021, 26(18):5665.
  • Front Pharmacol.2020, 11:683.
  • Molecules.2019, 24(11):E2102
  • Institut Pasteur Korea2020, doi: 10.21203.
  • Antioxidants (Basel).2022, 11(8):1471.
  • Phytomedicine.2019, 62:152962
  • Exp Parasitol.2015, 153:160-4
  • Chem Res Toxicol. 2022, acs.chemrestox.2c00049.
  • Lab Chip.2018, 18(6):971-978
  • Planta Med.2018, 84(6-07):465-474
  • Ulm University Medical Center2020, doi: 10.18725.
  • Molecules2022, 27(12):3903.
  • J Pharm Anal.2016, 6(6):363-373
  • Korean Journal of Pharmacognosy2017, 48(4):320-328
  • FASEB J.2019, 33(8):9685-9694
  • Molecules.2020, 25(21):5087.
  • J Vet Sci.2020, 21(3):e39.
  • J of Dentistry & Oral Health2019, 2641-1962
  • Sci Rep. 2018, 1-9
  • Antioxidants (Basel).2021, 10(8):1300.
  • ...
  • 生物活性
    Description: Reference standards.
    In vitro:
    Frontiers in Immunology, 2017, 8:925.
    DT-13 Ameliorates TNF-α-Induced Vascular Endothelial Hyperpermeability via Non-Muscle Myosin IIA and the Src/PI3K/Akt Signaling Pathway.[Pubmed: 28855900 ]
    DT-13((25RS)-ruscogenin-1-O-[β-d-glucopyranosyl-(1→2)][β-d-xylopyranosyl-(1→3)]-β-d-fucopyranoside) has been identified as an important factor in TNF-α-induced vascular inflammation. However, the effect of DT-13 on TNF-α-induced endothelial permeability and the potential molecular mechanisms remain unclear.
    METHODS AND RESULTS:
    Hence, this study was undertaken to elucidate the protective effect of DT-13 on TNF-α-induced endothelial permeability and the underlying mechanisms in vivo and in vitro. The in vivo results showed that DT-13 could ameliorate endothelial permeability in mustard oil-induced plasma leakage in the skin and modulate ZO-1 organization. In addition, the in vitro results showed that pretreatment with DT-13 could increase the transendothelial electrical resistance value and decrease the sodium fluorescein permeability coefficient. Moreover, DT-13 altered the mRNA and protein levels of ZO-1 as determined by real-time PCR, Western blotting, and immunofluorescence analyses. DT-13 treatment decreased the phosphorylations of Src, PI3K, and Akt in TNF-α-treated human umbilical vein endothelial cells (HUVECs). Further analyses with PP2 (10 µM, inhibitor of Src) indicated that DT-13 modulated endothelial permeability in TNF-α-induced HUVECs in an Src-dependent manner. LY294002 (10 µM, PI3K inhibitor) also had the same effect on DT-13 but did not affect phosphorylation of Src. Following decreased expression of non-muscle myosin IIA (NMIIA), the effect of DT-13 on the phosphorylations of Src, PI3K, and Akt was abolished.
    CONCLUSIONS:
    This study provides pharmacological evidence showing that DT-13 significantly ameliorated the TNF-α-induced vascular endothelial hyperpermeability through modulation of the Src/PI3K/Akt pathway and NMIIA, which play an important role in this process.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3222 mL 11.6112 mL 23.2223 mL 46.4447 mL 58.0558 mL
    5 mM 0.4644 mL 2.3222 mL 4.6445 mL 9.2889 mL 11.6112 mL
    10 mM 0.2322 mL 1.1611 mL 2.3222 mL 4.6445 mL 5.8056 mL
    50 mM 0.0464 mL 0.2322 mL 0.4644 mL 0.9289 mL 1.1611 mL
    100 mM 0.0232 mL 0.1161 mL 0.2322 mL 0.4644 mL 0.5806 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    尼洛替星; Niloticin CFN99254 115404-57-4 C30H48O3 = 456.7 5mg QQ客服:2056216494
    胡黄连苷I; Picroside I CFN99565 27409-30-9 C24H28O11 = 492.47 20mg QQ客服:1413575084
    叶下珠脂素; Phyllanthin CFN99050 10351-88-9 C24H34O6 = 418.5 10mg QQ客服:2056216494
    4(15),11-Oppositadien-1-ol; 4(15),11-Oppositadien-1-ol CFN97193 70389-96-7 C15H24O = 220.4 5mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产