Info: Read More
  • 中药标准品生产商,产品定制服务
  • 2'-甲氧基苦参黄素

    2'-Methoxykurarinone

    2'-甲氧基苦参黄素
    产品编号 CFN92004
    CAS编号 270249-38-2
    分子式 = 分子量 C27H32O6 = 452.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Sophora flavescens Ait.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    2'-甲氧基苦参黄素 CFN92004 270249-38-2 1mg QQ客服:1457312923
    2'-甲氧基苦参黄素 CFN92004 270249-38-2 5mg QQ客服:1457312923
    2'-甲氧基苦参黄素 CFN92004 270249-38-2 10mg QQ客服:1457312923
    2'-甲氧基苦参黄素 CFN92004 270249-38-2 20mg QQ客服:1457312923
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Monash University Malaysia (Malaysia)
  • University of Lodz (Poland)
  • University of Minnesota (USA)
  • University of Brasilia (Brazil)
  • University of Ioannina (Greece)
  • The Ohio State University (USA)
  • Ateneo de Manila University (Philippines)
  • Charles University in Prague (Czech Republic)
  • University of Virginia (USA)
  • Universidade do Porto (Portugal)
  • Northeast Normal University Changchun (China)
  • Universite Libre de Bruxelles (Belgium)
  • University of Illinois (USA)
  • Celltrion Chemical Research Institute (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biochem Pharmacol. 2020, 177:114014.
  • Int Immunopharmacol.2019, 71:361-371
  • Food Sci Biotechnol.2021, 30(2):217-226.
  • Industrial Crops and Products2021, 163:113313.
  • PLoS One.2017, 12(8):e0181191
  • Sci Rep.2017, 7(1):3249
  • J Sep Sci.2019, 42(21):3352-3362
  • J Ethnopharmacol.2020, 249:112396
  • Front Pharmacol.2021, 12:765521.
  • Antioxidants (Basel).2020, 9(4):284.
  • Phytother Res.2022, 10.1002:ptr.7602.
  • Universidade Estadual Paulista2017, 42785
  • Molecules.2021, 26(6):1635.
  • Curr Issues Mol Biol.2023, ;45(2):1601-1612.
  • Metabolites.2020, 10(11):440.
  • Drug Des Devel Ther.2023, 17:2461-2479.
  • Indian J. of Experimental Bio.2020, 9(58).
  • Food Sci Nutr.2023, 00:1-10.
  • J Cell Mol Med.2023, 27(11):1592-1602.
  • Saudi Pharmaceutical Journal2023, 31(12):101829
  • Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
  • Front Pharmacol.2022, 13:806869.
  • ACS Pharmacol. Transl. Sci.2023, 3c00129.
  • ...
  • 生物活性
    Description: 2'-Methoxykurarinone has strong alpha-glucosidase inhibitory activities, with IC(50) values of 155 microM. 2'-Methoxykurarinone is a noncompetitive inhibitor of protein tyrosine phosphatase 1B, it exhibits cellular activity in the insulin signaling pathway by increasing the insulin-stimulated Akt phosphorylation level in human hepatocellular liver carcinoma HepG2 cells, suggesting its potential for new anti-insulin-resistant drug developments. 2′-Methoxykurarinone exhibits lethal activity against Trypanosoma cruzi.,the minimum lethal concentrations is 6.9 uM.
    Targets: Antifection | Akt
    In vitro:
    Planta Med., 2014, 80(7):557-60.
    Protein tyrosine phosphatase 1B inhibitory activity of lavandulyl flavonoids from roots of Sophora flavescens.[Pubmed: 24782228]
    Protein tyrosine phosphatase 1B is a non-transmembrane protein tyrosine phosphatase and major negative regulator in insulin signaling cascades, and much attention has been paid to protein tyrosine phosphatase 1B inhibitors as potential therapies for diabetes.
    METHODS AND RESULTS:
    The screening of a natural compound library led to the discovery of five lavandulyl flavonoids, which were isolated from the roots of Sophora flavescens, as novel PTP1B inhibitors: kuraridin (1), norkurarinone (2), kurarinone (3), 2'-Methoxykurarinone (4), and kushenol T (5). The three most potent compounds, 1, 2, and 4 (IC50 < 30 μM), were demonstrated to be noncompetitive inhibitors of protein tyrosine phosphatase 1B based on a kinetic analysis, and they exhibited different inhibitory selectivities against four homologous protein tyrosine phosphatases (T cell protein tyrosine phosphatase, vaccinia H1-related phosphatase, and Src homology domain 2-containing protein tyrosine phosphatases 1 and 2).
    Natural Medicines, 2003, 57:253-5.
    Trypanocidal Flavonoids from Sophora flavescens[Reference: WebLink]
    The acetone extract of Sophora flavescens Aiton (Leguminosae) exhibited lethal activity against Trypanosoma cruzi.
    METHODS AND RESULTS:
    Column chromatographic separation of the extract guided by trypanocidal activity afforded a new prenylated flavanone (4), together with nine known flavonoids: sophoraflavanone G (1), (-) -kurarinone (2), kushenol L (3), 2'-Methoxykurarinone, (5), 7,4′-dihydroxy-5-methoxy-8-(γ,γ-dimethylallyl)-flavanone (6), leachianone A (7), 8-prenylnaringenin (8), noranhydroicaritin (9) and alopecurone G (10). The structure of the new flavanone 4 was determined on the basis of spectroscopic analyses.
    CONCLUSIONS:
    The minimum lethal concentrations of these compounds against epimastigotes of T. cruzi were 3.7 μM (1), 14 μM (2), 7.1 μM (3), 7.2 μM (4), 6.9 μM (5), 71 μM (6), 5.5 μM (7), 18 μM (8), 4.4 μM (9) and 3.6 μM (10).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2095 mL 11.0473 mL 22.0946 mL 44.1891 mL 55.2364 mL
    5 mM 0.4419 mL 2.2095 mL 4.4189 mL 8.8378 mL 11.0473 mL
    10 mM 0.2209 mL 1.1047 mL 2.2095 mL 4.4189 mL 5.5236 mL
    50 mM 0.0442 mL 0.2209 mL 0.4419 mL 0.8838 mL 1.1047 mL
    100 mM 0.0221 mL 0.1105 mL 0.2209 mL 0.4419 mL 0.5524 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    槐黄烷酮G; Sophoraflavanone G CFN92005 97938-30-2 C25H28O6 = 424.5 20mg QQ客服:1413575084
    苦参新醇 F; Kushenol F CFN93051 34981-24-3 C25H28O6 = 424.5 5mg QQ客服:215959384
    苦参黄素,苦参酮; Kurarinone CFN92003 34981-26-5 C26H30O6 = 438.5 20mg QQ客服:1413575084
    苦参醇; Kurarinol CFN92533 855746-98-4 C26H32O7 = 456.5 5mg QQ客服:2159513211
    里查酮A; Leachianone A CFN97560 97938-31-3 C26H30O6 = 438.5 5mg QQ客服:1457312923
    2'-甲氧基苦参黄素; 2'-Methoxykurarinone CFN92004 270249-38-2 C27H32O6 = 452.6 5mg QQ客服:1413575084
    苦参醇B; Kushenol B CFN92348 99217-64-8 C30H36O6 = 492.6 5mg QQ客服:215959384
    槐黄烷酮 I; Sophoraflavanone I CFN96552 136997-69-8 C39H38O9 = 650.72 5mg QQ客服:3257982914
    槐黄烷酮 H; Sophoraflavanone H CFN96553 136997-68-7 C34H30O9 = 582.60 5mg QQ客服:1413575084
    Alopecurone A; Alopecurone A CFN95512 162558-89-6 C39H38O9 = 650.7 10mg QQ客服:2056216494

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产