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  • 2-乙酰苯甲酸

    2-Acetylbenzoic acid

    2-乙酰苯甲酸
    产品编号 CFN98978
    CAS编号 577-56-0
    分子式 = 分子量 C9H8O3 = 164.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The herbs of Impatiens balsamina.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    2-乙酰苯甲酸 CFN98978 577-56-0 10mg QQ客服:1457312923
    2-乙酰苯甲酸 CFN98978 577-56-0 20mg QQ客服:1457312923
    2-乙酰苯甲酸 CFN98978 577-56-0 50mg QQ客服:1457312923
    2-乙酰苯甲酸 CFN98978 577-56-0 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Kyoto University (Japan)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Gyeongsang National University (Korea)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • University of Maryland (USA)
  • Universidad de Buenos Aires (Argentina)
  • Monash University Malaysia (Malaysia)
  • University of Oslo (Norway)
  • Mendel University in Brno (Czech Republic)
  • Universitas islam negeri Jakarta (Indonesia)
  • Auburn University (USA)
  • Tokyo Woman's Christian University (Japan)
  • Deutsches Krebsforschungszentrum (Germany)
  • Univerzita Karlova v Praze (Czech Republic)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Arch Biochem Biophys.2018, 644:93-99
  • Inflammation.2021, doi: 10.1007
  • Phytother Res.2019, 33(5):1490-1500
  • bioRxiv2021, 458409.
  • Applied Biological Chemistry2023, 66:85.
  • Molecules. 2013, 18(7):7376-88
  • Food and Chemical Toxicology2020, 111221
  • ACS Pharmacol. Transl. Sci.2023, 3c00129.
  • Nutrients.2020, 12(12):3607.
  • Nat Commun.2021, 12(1):681.
  • Industrial Crops and Products2022, 186:115298
  • J Med Food.2021, 24(2):151-160.
  • FEMS Microbiol Lett.2017, 364(11)
  • J Adv Res.2021, 35:245-257.
  • Journal of Ginseng Research2021, 3 June.
  • J Sci Food Agric.2023, 103(1):213-220.
  • Korean Journal of Pharmacognosy.2020, 51(2):100-106
  • Metab Eng.2022, 75:143-152.
  • Pharm Biol.2016, 54(7):1255-62
  • Plants (Basel).2021, 10(4):702.
  • Molecules.2021, 26(6):1635.
  • BMC Plant Biol.2021, 21(1):60.
  • BMC Complement Altern Med.2016, 16:213
  • ...
  • 生物活性
    Description: 2-Acetylbenzoic acid is more potent than 2-propionyloxybenzoic acid in inhibiting platelet function and platelet prostaglandin (PG) synthesis although the potencies of these agents were comparable in inhibiting prostacyclin (PGI2) synthesis.
    Targets: PGE
    In vitro:
    Prostaglandins Leukot Med. 1982 Jul;9(1):9-23.
    Structure-activity studies of aspirin and related compounds on platelet aggregation, arachidonic acid metabolism in platelets and artery, and arterial prostacyclin activity.[Pubmed: 6813878 ]

    METHODS AND RESULTS:
    A series of benzoic acid derivatives was tested for specificity of action on human platelet function and platelet prostaglandin (PG) synthesis versus prostacyclin (PGI2) production by rat and rabbit aorta rings. None of the agents tested was more specific for one system than the other. ASA was more potent than 2-propionyloxybenzoic acid (2-PBA) in inhibiting platelet function and platelet PG synthesis although the potencies of these agents were comparable in inhibiting PGI2 synthesis. 3-Propionyloxybenzoic acid (3-PBA) caused increased activity in both systems while 2-acetylbenzoic acid (ABA) had only minor effects. A cyclical derivative, 3-methylphthalide (3-MP), inhibited both platelet function and PGI2 synthesis although it did not inhibit cyclo-oxygenase activity, suggesting a novel mechanism of action.
    CONCLUSIONS:
    Thus only minor changes in the ASA molecule could be effected without significant changes in pharmacological activity. The investigation of novel agents such as 3-MP may lead to a better understanding of arachidonate metabolism in different tissues and possibly to the development of more tissue-specific drugs.
    In vivo:
    Agents Actions. 1981 May;11(3):281-6.
    Relationship of inhibition of prostaglandin synthesis in platelets to anti-aggregatory and anti-inflammatory activity of some benzoic acid derivatives.[Pubmed: 7257955]
    The relationships between inhibition of platelet prostaglandin (PG) synthesis and aggregation, and suppression inflammation were investigated with a number of benzoic acid (aspirin-like) chemicals.
    METHODS AND RESULTS:
    The compounds studied were 2-acetylbenzoic acid (ABA), 3-methylphthalide (3-MP), 3-propionyloxybenzoic acid (3-PBA) and 2-propionyloxybenzoic acid (2-PBA). At 0.5--0.6 mM, 3-MP inhibited the second phase of ADP-induced aggregation in human platelets, and reduced collagen-induced aggregation by 50%. Previous studies have shown 2-PBA to inhibit aggregation at similar concentrations. In contrast, ABA required 10 times higher concentrations, and low concentrations actually potentiated aggregation. Inhibition of PG synthesis from 14C-arachidonic acid (AA) by human platelets was shown for 2-PBA, but not to 3-BPA, or ABA. At high concentration (1 mM), 3-MP showed modest inhibitory activity. Significant inhibition of AA aggregation was produced by ASA (83%), 2-PBA (76%) and 3-MP (69%), an order reflecting their inhibition of PG synthesis, where ABA and 3-PBA did not inhibit AA aggregation. Carrageenin-induced edema of the rat paw was suppressed by 3-MP, ABA and 2-PBA; all being roughly equipotent with aspirin. In contrast, 3-PBA did not suppress edema. Following oral administration of the drugs to rats, PG synthesis from labeled AA by rat platelets showed similar profiles to effects of the drugs on PG synthesis in human platelets.
    CONCLUSIONS:
    This suggests that biotransformation or species differences are not explanations for the observed differences in activity in the various test systems. The results indicate that, in a related series of chemicals there is not a good correlation between ability to inhibit platelet PG synthesis, anti-aggregatory activity and anti-inflammatory activity. Multiple mechanisms of action, differing sensitivities of various tissue PG synthetases, or unidentified factors could be involved.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.0901 mL 30.4507 mL 60.9013 mL 121.8027 mL 152.2533 mL
    5 mM 1.218 mL 6.0901 mL 12.1803 mL 24.3605 mL 30.4507 mL
    10 mM 0.609 mL 3.0451 mL 6.0901 mL 12.1803 mL 15.2253 mL
    50 mM 0.1218 mL 0.609 mL 1.218 mL 2.4361 mL 3.0451 mL
    100 mM 0.0609 mL 0.3045 mL 0.609 mL 1.218 mL 1.5225 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4-(葡糖糖氧基)-肉桂酸葡萄糖氧基苄酯; Shancigusin I CFN95061 1435488-35-9 C28H34O14 = 594.6 5mg QQ客服:2159513211
    Bletilloside A; Bletilloside A CFN91183 2292159-89-6 C29H36O15 = 624.6 5mg QQ客服:2056216494
    3-甲氧基-4-(葡糖糖氧基)-肉桂酸葡萄糖氧基苄酯; 3-Methoxyshancigusin I CFN95062 N/A C29H36O15 = 624.6 5mg QQ客服:3257982914
    水杨酸; Salicylic acid CFN93274 69-72-7 C7H6O3 = 138.12 20mg QQ客服:2159513211
    2-乙酰苯甲酸; 2-Acetylbenzoic acid CFN98978 577-56-0 C9H8O3 = 164.2 20mg QQ客服:2056216494
    邻羧基苯甲醛; 2-Carboxybenzaldehyde CFN90128 119-67-5 C8H6O3 = 150.13 20mg QQ客服:2159513211
    邻苯二甲酸二甲酯; 避蚊酯; Dimethyl phthalate CFN99401 131-11-3 C10H10O4 = 194.2 20mg QQ客服:1413575084
    绣线菊苷; Helicin CFN70171 618-65-5 C13H16O7 = 284.3 20mg QQ客服:1413575084
    冬绿苷; Gaultherin CFN90338 490-67-5 C19H26O12 = 446.40 5mg QQ客服:1413575084
    红果酸; Eucomic acid CFN95364 42151-32-6 C11H12O6 = 240.2 5mg QQ客服:1413575084

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