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  • 2,3-二氢-3alpha-甲氧基印苦楝内酯

    2,3-Dihydro-3alpha-methoxynimbolide

    2,3-二氢-3alpha-甲氧基印苦楝内酯
    产品编号 CFN96791
    CAS编号 1607828-35-2
    分子式 = 分子量 C28H34O8 = 498.57
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The barks of Azadirachta indica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    2,3-二氢-3alpha-甲氧基印苦楝内酯 CFN96791 1607828-35-2 1mg QQ客服:2056216494
    2,3-二氢-3alpha-甲氧基印苦楝内酯 CFN96791 1607828-35-2 5mg QQ客服:2056216494
    2,3-二氢-3alpha-甲氧基印苦楝内酯 CFN96791 1607828-35-2 10mg QQ客服:2056216494
    2,3-二氢-3alpha-甲氧基印苦楝内酯 CFN96791 1607828-35-2 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J.Food Processing & Preservation2022, jfpp.16666
  • Microbiol. Biotechnol. Lett.2022, 50(2): 193-201.
  • PLoS One.2018, 13(4):e0195642
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  • Anal Bioanal Chem.2018, 410(5):1561-1569
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  • Plants (Basel).2022, 11(16):2126.
  • Appl. Sci.2021, 11(19),9343.
  • Evid Based Complement Alternat Med.2020, 2020:1970349.
  • Clin Exp Pharmacol Physiol.2020, doi: 10.1111
  • Nutrients.2020, 12(5):1242.
  • Molecules.2021, 26(9):2802.
  • Cell Metab.2020, S1550-4131(20)30002-4
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  • Chem. of Vegetable Raw Materials2020, 97-105
  • ...
  • 生物活性
    Description: 2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in stomach (AZ521) cancer cell line.
    Targets: Bcl-2/Bax | Caspase
    In vitro:
    Chem Biodivers. 2014 Apr;11(4):505-31.
    Limonoids from Azadirachta indica var. siamensis extracts and their cytotoxic and melanogenesis-inhibitory activities.[Pubmed: 24706622 ]
    Six new limonoids, 7-benzoyl-17-epinimbocinol (5), 3-acetyl-7-tigloylnimbidinin (8), 1-isovaleroyl-1-detigloylsalanninolide (15), 2,3-Dihydro-3alpha-methoxynimbolide (16), deacetyl-20,21-epoxy-20,22-dihydro-21-deoxyisonimbinolide (26), and deacetyl-20,21,22,23-tetrahydro-20,22-dihydroxy-21,23-dimethoxynimbin (27), along with 28 known limonoids, 1-4, 6, 7, 9-14, 17-25, and 28-34, and two known flavonoids, 35 and 36, have been isolated from the extracts of bark, leaves, roots, and seeds of Azadirachta indica A. Juss. var. siamensis Valeton (Siamese neem tree; Meliaceae).
    METHODS AND RESULTS:
    The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis and comparison with literature data. All of these compounds were evaluated for their cytotoxic activities against leukemia (HL60), lung (A549), stomach (AZ521), and breast (SK-BR-3) cancer cell lines. Eleven compounds, 1, 2, 4-7, 13, 16, 17, 29, and 30, exhibited potent cytotoxicities against one or more cell lines with IC50 values in the range of 0.1-9.3 μM. Compound 16 induced apoptotic cell death in AZ521 cells upon evaluation of the apoptosis-inducing activity by flow cytometric analysis. Western blot analysis on AZ521 cells revealed that compound 16 activated caspases-3, -8, and -9, while increasing the ratio of Bax/Bcl-2.
    CONCLUSIONS:
    This suggested that 16 induced apoptosis via both mitochondrial and death receptor pathways in AZ521.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0057 mL 10.0287 mL 20.0574 mL 40.1147 mL 50.1434 mL
    5 mM 0.4011 mL 2.0057 mL 4.0115 mL 8.0229 mL 10.0287 mL
    10 mM 0.2006 mL 1.0029 mL 2.0057 mL 4.0115 mL 5.0143 mL
    50 mM 0.0401 mL 0.2006 mL 0.4011 mL 0.8023 mL 1.0029 mL
    100 mM 0.0201 mL 0.1003 mL 0.2006 mL 0.4011 mL 0.5014 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    1-Deacetylnimbolinin B; 1-Deacetylnimbolinin B CFN97244 76689-98-0 C33H44O9 = 584.7 5mg QQ客服:215959384
    28-去氧代印苦楝内酯; 28-Deoxonimbolide CFN97835 126005-94-5 C27H32O6 = 452.55 5mg QQ客服:215959384
    印苦楝内酯; Nimbolide CFN91919 25990-37-8 C27H30O7 = 466.52 10mg QQ客服:1457312923
    2,3-二氢-3alpha-甲氧基印苦楝内酯; 2,3-Dihydro-3alpha-methoxynimbolide CFN96791 1607828-35-2 C28H34O8 = 498.57 5mg QQ客服:2159513211
    脱乙酰基印楝素; Deacetylnimbin CFN97797 18609-16-0 C28H34O8 = 498.57 5mg QQ客服:1457312923
    印楝素; Nimbin CFN97722 5945-86-8 C30H36O9 = 540.61 5mg QQ客服:1413575084
    2'-3'-dehydrosalannol; 2',3'-Dehydrosalannol CFN97589 97411-50-2 C32H42O8 = 554.68 5mg QQ客服:2056216494
    去乙酰印楝沙兰林; Deacetylsalannin CFN97855 1110-56-1 C32H42O8 = 554.68 5mg QQ客服:3257982914
    印楝沙兰林; Salannin CFN91920 992-20-1 C34H44O9 = 596.71 5mg QQ客服:215959384
    Ohchinin; Ohchinin CFN97704 67023-80-7 C36H42O8 = 602.73 5mg QQ客服:215959384

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