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  • 10-羟基-6-铁屎米酮

    10-Hydroxycanthin-6-one

    10-羟基-6-铁屎米酮
    产品编号 CFN94012
    CAS编号 86293-41-6
    分子式 = 分子量 C14H8N2O2 = 236.23
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Alkaloids
    植物来源 The barks of Picrasma quassioides (D.Don) Benn
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    10-羟基-6-铁屎米酮 CFN94012 86293-41-6 1mg QQ客服:2056216494
    10-羟基-6-铁屎米酮 CFN94012 86293-41-6 5mg QQ客服:2056216494
    10-羟基-6-铁屎米酮 CFN94012 86293-41-6 10mg QQ客服:2056216494
    10-羟基-6-铁屎米酮 CFN94012 86293-41-6 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Illinois (USA)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • University of Melbourne (Australia)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Macau University of Science and Technology (China)
  • Julius Kühn-Institut (Germany)
  • Universit?t Basel (Switzerland)
  • University of Padjajaran (Indonesia)
  • Copenhagen University (Denmark)
  • Sapienza University of Rome (Italy)
  • Srinakharinwirot University (Thailand)
  • Heidelberg University (Germany)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Yale University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Chem.2019, 279:80-87
  • University of Guelph2021, 12.
  • Molecules.2020, 25(20):4851.
  • Br J Pharmacol.2018, 175(6):902-923
  • Food Res Int.2018, 106:909-919
  • Tissue Cell.2022, 75:101728.
  • Drug Dev Res.2020, doi: 10.1002
  • Jour. of Stored Pro & Postharvest Res.2016, 7(3):32-36
  • Phytomedicine.2019, 56:48-56
  • Food Science and Biotechnology2022, 10.1007.
  • Food Res Int.2020, 128:108778
  • Sci Rep. 2018, 1-9
  • bioRxiv2021, 462065.
  • Ulm University Medical Center2020, doi: 10.18725.
  • Pharmaceutics.2020, 12(9):845.
  • J Pharm Biomed Anal2016, 118:183-194
  • Nutr Res Pract2019, 13:e45
  • Phytother Res.2015, 29(7):1088-96
  • Sci Rep.2019, 9(1):6429
  • Acta Agriculturae Scandinavica2015, 381-383
  • ACS Omega2020, 5,33,20825-20830
  • Pharmacognosy Magazine2017, 13(52):868-874
  • Mol Med Rep.2022, 25(1):8.
  • ...
  • 生物活性
    Description: 10-Hydroxycanthin-6-one has potential to be an antimicrobial agent. 10-Hydroxycanthin-6-one has in vitro antimalarial activity; it also has cytotoxic activity, it could be a plant anticancer agent.
    Targets: Antifection
    In vitro:
    Molecules, 2016, 21(3):390
    Synthesis and Evaluation of Ester Derivatives of 10-Hydroxycanthin-6-one as Potential Antimicrobial Agents.[Pubmed: 27007362 ]
    As part of our continuing research on canthin-6-one antimicrobial agents, a new series of ester derivatives of 10-Hydroxycanthin-6-one were synthesized using a simple and effective synthetic route.
    METHODS AND RESULTS:
    The structure of each compound was characterized by NMR, ESI-MS, FT-IR, UV, and elemental analysis. The antimicrobial activity of these compounds against three phytopathogenic fungi (Alternaria solani, Fusarium graminearum, and Fusarium solani) and four bacteria (Bacillus cereus, Bacillus subtilis, Ralstonia solanacearum, and Pseudomonas syringae) were evaluated using the mycelium linear growth rate method and micro-broth dilution method, respectively. The structure-activity relationship is discussed. Of the tested compounds, 4 and 7s displayed significant antifungal activity against F. graminearum, with inhibition rates of 100% at a concentration of 50 μg/mL. Compounds 5, 7s, and 7t showed the best inhibitory activity against all the tested bacteria, with minimum inhibitory concentrations (MICs) between 3.91 and 31.25 μg/mL.
    CONCLUSIONS:
    Thus, 7s emerged as a promising lead compound for the development of novel canthine-6-one antimicrobial agents.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.2332 mL 21.1658 mL 42.3316 mL 84.6633 mL 105.8291 mL
    5 mM 0.8466 mL 4.2332 mL 8.4663 mL 16.9327 mL 21.1658 mL
    10 mM 0.4233 mL 2.1166 mL 4.2332 mL 8.4663 mL 10.5829 mL
    50 mM 0.0847 mL 0.4233 mL 0.8466 mL 1.6933 mL 2.1166 mL
    100 mM 0.0423 mL 0.2117 mL 0.4233 mL 0.8466 mL 1.0583 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    铁屎米酮; Canthin-6-one CFN98730 479-43-6 C14H8N2O = 220.2 5mg QQ客服:215959384
    铁屎米酮 N氧化物; Canthin-6-one N-oxide CFN92010 60755-87-5 C14H8N2O2 = 236.2 5mg QQ客服:215959384
    1-羟基-6-铁屎米酮; 1-Hydroxycanthin-6-one CFN97287 80787-59-3 C14H8N2O2 = 236.2 5mg QQ客服:3257982914
    9-羟基铁屎米酮; 9-Hydroxycanthin-6-one CFN92126 138544-91-9 C14H8N2O2 = 236.2 5mg QQ客服:3257982914
    10-羟基-6-铁屎米酮; 10-Hydroxycanthin-6-one CFN94012 86293-41-6 C14H8N2O2 = 236.23 5mg QQ客服:2056216494
    9-甲氧基铁屎米酮; 9-Methoxycanthin-6-one CFN92011 74991-91-6 C15H10N2O2 = 250.3 5mg QQ客服:215959384
    9-甲氧基铁屎米酮 N氧化物; 9-Methoxycanthin-6-one-N-oxide CFN92012 137739-74-3 C15H10N2O3 = 266.3 5mg QQ客服:1413575084
    1-羟基-9-甲氧基铁屎米酮; 1-Hydroxy-9-medroxycanthin-6-one CFN92124 622408-85-9 C15H10N2O3 = 266.3 5mg QQ客服:1413575084
    11-羟基-6-铁屎米酮; 11-Hydroxycanthin-6-one CFN92125 75969-83-4 C14H8N2O2 = 236.2 5mg QQ客服:2056216494
    9,10-二甲氧基铁屎米酮; 9,10-Dimethoxycanthin-6-one CFN92127 155861-51-1 C16H12N2O3 = 280.3 5mg QQ客服:215959384

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