1,7-Dihydroxy-2,3-methylenedioxyxanthone

	产品编号	CFN89260
	CAS编号	183210-63-1
	分子式 = 分子量	C₁₄H₈O₆ = 272.21
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Xanthones
	植物来源	The roots of Polygala fallax.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
1,7-Dihydroxy-2,3-methylenedioxyxanthone	CFN89260	183210-63-1	1mg	QQ客服：215959384
1,7-Dihydroxy-2,3-methylenedioxyxanthone	CFN89260	183210-63-1	5mg	QQ客服：215959384
1,7-Dihydroxy-2,3-methylenedioxyxanthone	CFN89260	183210-63-1	10mg	QQ客服：215959384
1,7-Dihydroxy-2,3-methylenedioxyxanthone	CFN89260	183210-63-1	20mg	QQ客服：215959384

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

1,7-Dihydroxy-2,3-methylenedioxyxanthone has antiulcerogenic, anti-oxidation, and antihyperalgesic activities, it can inhibit the carrageenan-induced hyperalgesia.

Targets:

PGE | Antifection

In vitro:

Zhongguo Zhong Yao Za Zhi. 2005 Jun;30(11):827-30.

Chemical constituents in roots of Polygala fallax and their anti-oxidation activities in vitro.[Pubmed: 16110862]

To study the chemical constituents in roots of P. fallax and their anti-oxidation activities in vitro.
METHODS AND RESULTS:
Column chromatographic techniques were employed for isolation and purification of chemical constituents of the plant. The structures were elucidated on the basis of the spectral evidence and the physical and chemical character. The isolated compounds were screened with four anti-oxidation models in vitro. Seven xanthones, 1,7-Dihydroxy-2,3-methylenedioxyxanthone (1), 1-methoxy-2,3-methylenedioxyxanthone (2), 3-hydroxy-1,2-dimethoxyxanthone (3), 1,6,7-trihydroxy-2,3-dimethoxyxanthone (4), 7-hydroxy-1-methoxy-2,3-methylenedioxyxanthone (5), 1,3-dihydroxy-2-methoxyxanthone (6) and 1,3,7-trihydroxy-2-methoxyxanthone (7), were isolated from the roots of P. fallax. And compounds 1 - 7 showed different anti-oxidation activities in the different pharmacological models.
CONCLUSIONS:
Compounds 2, 3, 5 and 7 were isolated from this plant for the first time. Xanthones from this plant showed anti-oxidation activities. The pharmacological activities of the pure compounds from this plant were also reported for the first time.

In vivo:

Basic Clin Pharmacol Toxicol. 2012 Sep;111(3):145-53.

Antihyperalgesic activity of the methanol extract and some constituents obtained from Polygala cyparissias (Polygalaceae).[Pubmed: 22381005]

Polygala cyparissias, used in folk medicine as an anaesthetic, has already demonstrated antinociceptive activity against acute pain.
METHODS AND RESULTS:
In this study, we investigated the antihyperalgesic activity of the P. cyparissias methanol extract (PCME) from which the following compounds were isolated: α-spinasterol (PC1), 1,3-dihydroxy-7-methoxyxanthone (PC2), 1,7-Dihydroxy-2,3-methylenedioxyxanthone (PC3) and 1,3,6,8-tetrahydroxy-2,7-dimethoxyxanthone (PC4). The antihyperalgesic effect was evaluated using experimental models of persistent pain induced by carrageenan, lipopolysaccharide (LPS), Freund's Complete Adjuvant (CFA), PGE(2) or epinephrine. The partial ligation of the sciatic nerve (PLSN) model was also used. In inflammatory hyperalgesia induced by carrageenan, LPS, CFA or PGE(2), the inhibition values obtained with the PCME treatment were 68 ± 3%, 89 ± 5%, 43 ± 3% and 40 ± 4%, respectively. In epinephrine-induced hyperalgesia, the extract was effective, reducing 99 ± 11% of response frequency, while in PLSN, 54 ± 4% of inhibition was obtained. These results allow to suggest that the antihyperalgesic activity of PCME is, at least in part, related to its capability to inhibit the hypersensitization induced by pro-inflammatory mediators, such as LPS, carrageenan and CFA, without interfering with locomotor activity or motor performance. Furthermore, compounds PC1, PC3 and PC4 inhibited the carrageenan-induced hyperalgesia with inhibition of 42 ± 6%, 48 ± 5% and 64 ± 4%, respectively.
CONCLUSIONS:
In summary, our data demonstrate that PCME has relevant antihyperalgesic activity and that the isolated PC1, PC3 and PC4 seem to be responsible, at least in part, for this important effect.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.6736 mL	18.3682 mL	36.7363 mL	73.4727 mL	91.8409 mL
5 mM	0.7347 mL	3.6736 mL	7.3473 mL	14.6945 mL	18.3682 mL
10 mM	0.3674 mL	1.8368 mL	3.6736 mL	7.3473 mL	9.1841 mL
50 mM	0.0735 mL	0.3674 mL	0.7347 mL	1.4695 mL	1.8368 mL
100 mM	0.0367 mL	0.1837 mL	0.3674 mL	0.7347 mL	0.9184 mL

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
(1S)-野菊花醇丙酮; (1S)-Chrysanthemolactone	CFN70269	14087-71-9	C₁₀H₁₆O₂ = 168.2	5mg	QQ客服：1413575084
Volvaltrate B; Volvaltrate B	CFN96443	1181224-13-4	C₂₇H₄₁ClO₁₁ = 577.06	5mg	QQ客服：2056216494
Angustifoline; Angustifoline	CFN92233	550-43-6	C₁₄H₂₂N₂O = 234.3	5mg	QQ客服：1413575084
3-乙酰氧基-24-羟基达玛-20,25-二烯; 3-Acetoxy-24-hydroxydammara-20,25-diene	CFN99477	143519-04-4	C₃₂H₅₂O₃ = 484.8	5mg	QQ客服：1413575084

1,7-Dihydroxy-2,3-methylenedioxyxanthone

1,7-Dihydroxy-2,3-methylenedioxyxanthone

信息支持

联系方式